National Weekly Bulletin

Year: Week:


Week 11.12.2017-17.12.2017

Influenza and ARI morbidity data

Epidemiological data show increase of influenza and other ARI activity in Russia in comparison with previous week. The nationwide ILI & ARI morbidity level (68.5 per 10 000 of population) was lower than the national baseline (69.5) by 1.4%.

ILI and ARI epidemic thresholds were exceeded in two of 61 cities collaborating with two WHO NICs in Russia.

Exceeding of morbidity epidemic thresholds for overall population
 
- No data - less 20% - 20 - 49% - 50% and more


Cumulative number of diagnosed influenza cases

Cumulative results of influenza laboratory diagnosis by different tests were submitted by 54 RBLs and two WHO NICs. According to these data as a result of 2160 patients investigation the overall proportion of respiratory samples positive for influenza was estimated as 0.3%, including 0.2% for influenza A(H3N2) virus  and 0.05% for influenza type A virus

Results of influenza diagnosis
 
- No data
- No detection
- H1pdm09
- H1pdm09+H1
- H1pdm09+B
- H1pdm09+B+H1
- H1pdm09+H3
- H1pdm09+H3+H1
- H1pdm09+H3+B
- H1pdm09+H3+H1+B
- H1
- B
- B+H1
- H3
- H3+H1
- H3+B
- H3+H1+B


Influenza Virus Isolation



  - B - A(H1N1) - A(H3N2) - A(H1N1)pdm09  


Influenza Virus Antigen Detection by Immunofluorescence Assay (IFA)



  - B - A(H1N1) + A(H1N1)pdm09 - A(H3N2)  
  - PIV - AD - RS  


Influenza Virus RNA Detection by RT-PCR



  - B - A(H1N1) - A(H3N2) - A(H1N1)pdm09  
  - PIV - AD - RS    


Table 1. Influenza Virus Isolation
Base lab. Number of
investigated
patients
Number of viruses isolated
H1 H3 B H1pdm09 Untyped
virus
Total
BL of RII40000000
(%) 0,00,00,00,00,00,0
BL of IV0000000
(%) ------
TOTAL40000000
(%) 0,00,00,00,00,00,0

Table 2. Influenza Virus Antigen Detection by Immunofluorescence Assay (IFA)
Base lab. Number of
investigated
patients
Influenza Parainfluenza AD RS Total
H1+H1pdm09 H3 B I II III
BL of RII7080001713355833156
(%) 0,00,00,02,41,84,98,24,722,0
BL of IV114000631710541
(%) 0,00,00,05,32,614,98,84,436,0
TOTAL8220002316526838197
(%) 0,00,00,02,81,96,38,34,624,0

Table 3. Influenza Virus RNA Detection by RT-PCR
Base lab. Number of
investigated
patients
Influenza PIV AD RS
A
(not subtyped)
H1 H3 H5 B H1pdm09
BL of RII13921 / 16020 / 4454 / 6540 / 4350 / 13920 / 69631 / 102042 / 100882 / 999
(%) 0,060,00,60,00,00,03,04,28,2
BL of IV2360 / 2360 / 581 / 580 / 580 / 2360 / 582 / 17715 / 17712 / 177
(%) 0,00,01,70,00,00,01,18,56,8
TOTAL16281 / 18380 / 5035 / 7120 / 4930 / 16280 / 75433 / 119757 / 118594 / 1176
(%) 0,050,00,70,00,00,02,84,88,0

Table 4. Cumulative number of diagnosed influenza cases
Base lab. Number of
investigated
patients
Number of diagnosed influenza cases
H1 H1+H1pdm09
(IFA)
H3 A
(not subtyped)
B H1pdm09 Total
BL of RII18840041005
(%) 0,00,00,20,050,00,00,3
BL of IV2760010001
(%) 0,00,00,40,00,00,00,4
TOTAL21600051006
(%) 0,00,00,20,050,00,00,3

Conclusion

Influenza and ARI morbidity data.  Increased influenza and other ARI activity was registered during the week 50.2017 in traditional surveillance system in Russia. The nationwide ILI & ARI morbidity level (68.5 per 10 000 of population) was lower than the national baseline by 1.4%.

Etiology of ILI & ARI morbidity. The overall proportion of respiratory samples tested positive for influenza  was estimated as 0.3%, including 0.2% for influenza A(H3N2) virus and 0.05% for influenza type A virus. Percent of positive ARI cases of non-influenza etiology (PIV, adeno- and RSV) was estimated as 24.0% of investigated patients by IFA and 15.6% by PCR. 

Antigenic characterization. Five influenza A(H3N2) strains were antigenically related to influenza A/Hong Kong/4801/2014 virus.

Genetic characterizationOne influenza A(H3N2) virus was characterized in Saint-Petersburg NIC. Virus belonged to genetic subgroup 3C.2a1 and was like A/Bolzano/07/2016 referens virus. 4 influenza A(H3N2) strains from clinical samples were characterized in Saint-Petersburg NIC. Viruses belonged to genetic subgroup 3C.2a and were like A/HongKong/4801/2014 referens virus.

In sentinel surveillance system clinical samples from 137 SARI and ILI/ARI patients were investigated by rRT-PCR. Only one influenza A(H3N2) case was detected among ILI/ARI patients.