Targeted search for new virus-inhibiting substances based on the molecular biological features of viral reproduction. In vitro screening of chemical libraries and identification of components with high antiviral potential
Preliminary assessment of the acute toxicities of natural and synthetic compounds in cell culture and animals
Assessment of the specific antiviral activities of natural and synthetic compounds in animal models of viral infection, including influenza A/B, parainfluenza, herpes virus, adenovirus, enterovirus, etc.; characterization of the pathological processes caused by viral infection under various conditions, including drug treatment, using relevant virological, biochemical, immunological, morphological, and molecular biological techniques
Study of the mechanisms of protection behind effective antiviral compounds; modeling of the interactions between low molecular weight compounds and targets; molecular docking and the development of criteria for rational drug design and synthesis of specific ligands; evaluation of the effectiveness of developed compounds using computer models, cell-free systems, and cell culture models of viral infection
Monitoring the sensitivity of circulating viruses to clinical antiviral drugs; study of the efficacy of these drugs in relation to circulating strains; identification of resistant clinical isolates and characterization of their degrees of resistance
Over the past 5 years, as a result of research work, approximately forty scientific articles have been published and six Russian patents have been filed. Research has been conducted on the following projects
“Development of an innovative antiviral drug based on an imino-derived natural monoterpenoid” (2014-2015, state contract 14411 204 9999 19 085 dated October 22, 2014)
Implementation of the biological duties of the project "Creation of new drugs to combat resistant influenza strains through the directed transformation of natural terpenoids" (2015-2017, Russian Science Foundation project 15-13-00017)
Fulfillment of collaborative work on “Testing the anti-influenza activity of bi-functional IgG/IgA hybrid antibodies in model animals” (2016; contract with Moscow State University, as part of Russian Ministry of Education and Science project 14.607.21.0060 dated Sept. 23, 2014)
Fulfillment of collaborative work on “Study of the anti-influenza activity of bi-functional IgG/IgA hybrid antibodies using in vitro experiments” (2016; contract with Moscow State University, as part of Russian Ministry of Education and Science project 14.607.21.0060 dated Sept. 23, 2014)